الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hemarthrosis and pain are common complications after arthroscopic ACL reconstruction and can adversely affect the functional outcomes of ACL reconstruction in the early postoperative period.
The aim of this work was to evaluate the effect of intravenous tranexamic acid injection following arthroscopic anterior cruciate ligament reconstruction.
Through a prospective non randomized clinical trial, A total of 50 patients who underwent arthroscopic ACL reconstruction were enrolled and subdivided into two groups. A control group (n=25) who didn’t receive TXA. The experimental group (n=25) who received single intravenous dose of TXA (1 gm) 15 minutes before tourniquet application. The volume of drained blood was measured 24 hours postoperatively. Pain was evaluated using VAS score in the postoperative days (1, 2) and postoperative weeks (1, 2 and 6). Range of motion in the form of maximum flexion and extension of the knee were recorded in the postoperative days (1,2) and postoperative weeks (1, 2 and 6).
We found a statistically significant reduction in drainage blood volume in the test group compared with those in the control group. A significant improvement was found in ROM (Maximum flexion and extension angles) in the postoperative days (1 and 2) and postoperative weeks (1 and 2). In postoperative week 6, the difference in degree of maximum extension wasn’t statistically significant between the two groups. Pain outcome improved in the TXA group in postoperative days (1, 2) and postoperative weeks (1, 2 and 6). No any other complication was observed in the two groups except for low grade fever episodes which were higher in the control group than in the TXA group and that was statistically significant.
The results of this prospective study showed that TXA reduced the amount of postoperative hemarthrosis after arthroscopic ACL reconstruction. Consequently, TXA reduced pain and improved range of motion of the knee in the early postoperative period without side effects.