الفهرس 
Postpartum HemorrhageOnly 14 pages are availabe for public view
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Abstract
The aim of this work was to evaluate the effect of Tranexamic Acid in reduction of blood loss during and after elective Cesarean section. After approval of Local Ethical Committee and with written informed consent, the present study was carried out in Menoufia University Hospital and The Governorate Hospital for Birth (Dar Ismael Hospital),Alexandria on 74 healthy term pregnant females aged between 20-35 years old, scheduled for elective Cesarean section under spinal anesthesia. Patients were randomly categorized into two equal groups: Study group: Patients were received a bolus injection of one gram of intravenous tranexamic acid diluted in 20 ml of 5% Dextrose solution slowly over five to ten minutes at 10-20 minutes before skin incision, Oxytocin 10 units in 500ml 0.9% saline IV drip (8ml /min) was administrated after delivery of the fetus. Control group: No tranexamic acid was given; oxytocin was administered as in the study group. In this study:
- There was no significant difference between the two groups regarding age or weight.
- The mean gestational age in study group was 38.95 ± 1.03 weeks, while in control group was 38.73 ± 1.19 weeks, on comparing the gestational age in the two groups it was found that there was no significant difference between the two groups.
- The hemoglobin concentration before delivery in the two groups was matched without significant difference, while hemoglobin concentration
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decreased significantly in control group than study group, also on comparing the two groups after delivery it was found that there was a significant decrease in hemoglobin concenration in the control group than the study group.
- The Hematocrit values before delivery in the two groups was matched without significant difference, while Hematocrit values decreased significantly in control than study groups, also on comparing the two groups after delivery it was found that there was a significant decrease in Hematocrit values in the control than the study groups.
- Regarding Red blood cells (RBCs), platelets count and White blood cells (WBCs), it was found that there was no significant difference between the two study groups regarding RBCs, platelets or WBCs.
- Regarding Prothrombin time (PT), Partial thromboplastin time (PTT) and International normalized ratio (INR), on comparing the two groups regarding the PT, PTT and INR, it was found that there was no significant difference between the two study groups.
- Regarding amount of blood loss, it was found that the mean amount of blood loss in study group was 514.82 ± 33.16 ml, while in control group was 604.5 ± 40.23 ml, on comparing the two study groups it was found that there was a significant decrease in amount of blood loss in study group than the control group.