الفهرس 
Inflammation, Atherosclerosis and Coronary Artery DiseaseOnly 14 pages are availabe for public view
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Abstract
Atherosclerosis has been increasingly recognized as a complex and multifactorial inflammatory disease rather being a simply process of lipid accumulation of the wall of the medium sized and large arteries.
Inflammation plays a key role in the initiation, progression and complications of atherosclerosis by mediating every stage of the atheroma development.
This study aimed to evaluate the value of MHR as a predictor of coronary artery disease severity.
The present study is a prospective study which was conducted in National heart institute and the cardiology department of Menofyia university. Data was collected from 200 patients undergoing elective coronary angiography because of complaining of chest pain.
Patients were divided according to the syntax score into two groups:
group one: patients with Low syntax score <23 (n=140).
group two: patients with High syntax score ≥23 (n=60). .
They were assessed for baseline characteristics, laboratory data, angiographic result and their Syntax score.
According to Current Study:
Patients with High SX scores group were significantly older compared to those in Low SX scores (p <0.001). The severe atherosclerosis group and mild atherosclerosis group had significantly lower HDL levels compared to controls (p<0.001).
Summary
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Also males were signficantly higher in High syntax group (p<0.001).
The level of cholesterol and TG were significantly high in group II with high SYNTAX score (p<0.001).
MHR was significantly higher in the high syntax group compared to the low syntax (p<0.001).
MHR was found to be correlated with Syntax scores (r=0.570, p<0.001).
Using a cut-off level of 19.2, MHR predicted severe atherosclerosis with high syntax score with a sensitivity of 93.33% and specificity of 80%
MHR was independently associated with burden of coronary atherosclerosis assessed by SYNTAX score.