الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Many experimental and clinical studies showed that myoinositol has insulin-sensitizing effect in insulin resistance conditions as typically seen in type 2 diabetes mellitus (T2DM). Since there is a lack of evidence about the use of myoinositol in T2DM. Aim: Our study was conducted to assess the possible antidiabetic and antihyperlipidemic effects of myoinositol, compare its effect to those of metformin and evaluate if there are more beneficial effects when using both drugs together in an animal model of diabetes induced by high fat diet (HFD) / streptozotocin (STZ). Methods and drugs: 50 male Wister rats were randomly divided into 5 groups (10 per group), named as normal control group, diabetic control group, myoinositol treated group, metformin treated group and myoinositol+metformin treated group. After induction of type 2 diabetes, all drugs were taken for 4 weeks by gastric gavage. Parameters measured: Body weight (BW), fasting blood glucose level (FBG), fasting plasma insulin, homeostasis model assessment of insulin resistance (HOMA-IR), glucose disappearance rate (KITT%/minute) of insulin tolerance test, lipid profile and glucose transporter 4 (GLUT4) expression. Results: All treated groups showed non-significant change in BW, significant reduction in FBG, significant reduction in plasma insulin level, significant decrease in HOMA-IR and increase in KITT %/minute, significant improvement of lipid profile and significant increase in GLUT4 expression. The improvement of insulin resistance, hyperglycemic state and hyperlipidemia were better in combination therapy than in using either drug alone. Abstract 2 Conclusion: These findings suggest that myoinositol plays an effective role in glucose disposal into skeletal muscles by increasing GLUT4 expression that represents one of the most common causes of insulin resistance; hence, it may be used in the treatment of T2DM. In addition, combining myoinositol to metformin is more effective than using either drug alone |