الفهرس 
Introduction Aim of workOnly 14 pages are availabe for public view
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Abstract
Summary
Type 1 and type 2 DM have severe complications including DN. Diabetic nephropathy is one of the commonest causes of CKD.
Much research effort is being put into how to diagnose DN in diabetic patients. A large number of biomarker studies were published on markers in plasma or urine, either aiming to distinguish patients with or without DN, or with aiming to expect renal outcome in those patients with DN.
This cross-sectional observational study recruited 50 patients with longstanding T2DM and 20 healthy control subjects. Patients with T2DM were further stratified according to their urine albumin–creatinine ratio (UACR) into 3 groups ; normoalbuminuric , microalbuminuric and macroalbumuinuric . has miR-152 – 3p was quantified in blood using reverse transcription TaqMan microRNA assay..
The study showed that the has miR-152 – 3p levels were significantly higher in patients with lower eGFR and higher albumin/creatinine ratio
These findings may help to find a new marker for early detection of DN and this could be used in the future as a novel therapeutic target for the treatment of DN.