الفهرس 
PreeclampsiaOnly 14 pages are availabe for public view
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Abstract
Background: Pre-eclampsia is a pregnancy-specific disorder that has a worldwide prevalence of 5–8%. It is one of the main causes of maternal and perinatal morbidity and mortality globally and accounts for 50 000–60 00 deaths annually, with a predominance in the low- and middle-income countries. It is a multisystemic disorder however its aetiology, pathogenesis and pathophysiology are poorly understood. Aim of the Work: to assess the accuracy of maternal serum Cff-DNA concentration levels in primigravidas in their first half of pregnancy as a predictive test for the development of preeclampsia. Patients and Methods: A nested case-control study was conducted on 26 patients with PE and 26 matched controls rimigravidas in their first half of pregnancy i.e.≤ 20 weeks gestation recruited from Ain-Shams University Maternity Hospital. Laboratory work will be done in Ali Khalifa laboratory of the biochemistry department, Faculty of Medicine, Ain-Shams University. Results: The study showed a statistically significant increase median of severe preeclampsia compared to mild preeclampsia and control group according to cff-DNA (GE/ml). Also the study results revealed a statistically significant increase median of preeclampsia group compared to control group according to BMI, GA (wks), SBP and DBP. Conclusion: Cff-DNA quantification can be considered a promising marker for preeclampsia prediction, especially for the development of early-onset or severe preeclampsia.