الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
This is a cross sectional observational study has been carried out on 95 subjects at chest department, Minia university hospital, during the period from August 2018 to August 2019. The study included Thirty patients with stable ILDs, fifty patients with AE- ILD and fifteen healthy control.
This study aimed to determine the sensitivity and specificity of KL6 to detect AE-ILD and correlate between level of KL-6 and both functional and laboratory parameters.
All patients were subjected to the following:
History taking ,physical examination , mMRC dyspnea scale, Spirometry, Chest X ray, HRCT chest and ABGs analysis.
laboratory investigations were done for both patient and control groups including:
CBC, ESR, CRP, and Serum Human (KL6).
Patients were divided into 3 groups:
group I which is stable patients .
group II which is exacerbating patients.
Healthy control group.
In this study there was no statistical difference between group I (stable ILDs) II (AE-ILDs) and healthy control as regard age, sex and smoking status.
The study showed that there is a significant difference between stable and exacerbating groups regarding fever, Signs of RHF, and dyspnea scale.
We also found that patients with exacerbation had a statistically significant decrease in FVC, PaO2 and O2 saturation and a statistically significant increase in TLC and KL6 in comparison with stable one.
According to HRCT the ground glass and honeycombing appearance were more evident in exacerbation group (p= 0.003) .
There was a significant increase in KL6 level in IPF versus both hypersensitivity and CT disease (p=0.006 and 0.039) respectively .
ROC curve analysis of serum KL-6 to detect diagnosis of ILDs, the area under the curve was 1.000 at a cut-off value of 80 U/mL , sensitivity and specificity of 100%.
ROC curve analysis of serum KL-6 to detect AE-ILD , the area under the curve of 0.981 at a cut-off value of 187.5 U/mL ,sensitivity 98% and specificity 97% .
In this work there was a significant negative correlation between KL-6 , Total leukocytic count levels and both SO2 and FVC.
While there was no significant correlation between them (SO2 and FVC) with CRP or ESR.