الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Type 1 diabetes mellitus (T1DM) and immunoglobulin E-mediated allergies are common chronic diseases in pediatric. T helper (Th) cells play an important role in the development of both diseases. Th cells has 2 subtypes, called Th1 and Th2 cells. T1DM is caused by an autoimmune process which leads to a progressive destruction of pancreatic beta cells. The aim: Assessment of the relation between diabetes mellitus type 1 and development of IgE-mediated allergy. Our studied groups were subjected to: Interviewer-administrated questionnaire, was designed to take history of allergy in diabetic child come to outpatient clinic fulfilling inclusion criteria, history of allergy was confirmed by skin prick test done to diabetic allergic group and serum total IgE, IL5 and CBC for detection of eosinophils were sampled to both studied groups. The result: Manifestation of allergy among diabetic allergic group were 82% asthmatic, 40% allergic rhinitis and 31% skin allergy. There was significant difference between diabetic allergic group and diabetic non allergic group as regard artificial feeding and cumulative HbA1c. As regard allergens among diabetic allergic group, house dust mite was the highest percent of allergens, nearly half of the diabetic allergic group. There was significant difference between diabetic allergic group and diabetic non allergic group as regard levels of IL5, total IgE and eosinophils. IL5 levels have significant regression analysis in diabetic allergic group than diabetic non allergic group as regard asthma, allergic rhinitis and skin allergy (odds ratio 1.03, 1.02 and 1.02 respectively).