الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Background: Diabetic foot ulcers are among the most common complications of patients who have diabetes mellitus which is not well controlled. The standard practices in diabetic foot ulcers management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. Among adjuvant methods that appear to accelerate wound healing, negative-pressure wound therapy (NPWT) seems to be particularly effective in diabetic foot ulcerations. NPWT involves the use of a device that is connected to the wound bed through a special set and generates a negative pressure.
Objective: We conducted the present systematic review and meta-analysis in order to assess the short-term efficacy and safety data of NPWT use in patients with diabetes mellitus and concomitant neuropathic foot wounds.
Patients and methods: In the present study, we searched Medline via PubMed, SCOPUS, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar from their inception till March 2019. The search retrieved 1542 unique records. We then retained 58 potentially eligible records for full-texts screening. Finally, 11 RCTs (No. of patients = 972) were included in the present systematic review and meta-analysis.
Results: In the present systematic review and meta-analysis, the average age of the patients within the included studies was > 50 years old and the average BMI was around 30kg/m2. In terms of ulcer characteristics, calcaneal dorsal or plantar foot ulcer was the most common site of ulceration within the included studies. In the present study, the overall effect estimates favoured NPWT over conventional care for complete healing of the ulcer (RR 1.38, 95% CI [1.21 – 1.58]; P <0.001), reduction of time healing (MD -8.07, 95% CI [-13.7 – -2.45]; P =0.005), reduction of ulcer depth (MD -40.83, 95% CI [-45.65 – -36]; P <0.001), and reduction of ulcer area (MD -12.19, 95% CI [-15.87 – -8.5]; P <0.001).
Conclusion: In addition, six studies reported the rates of amputation. The overall effect estimates favoured NPWT over conventional care for amputation (RR 0.49, 95% CI [0.32 – 0.76]; P <0.001).