الفهرس 
الغلافOnly 14 pages are availabe for public view
 |  | from | 185 |  |  |
| | | from | 185 | | |
Abstract
During the search for promising bioactive secondary metabolites from
microorganisms, Streptomyces sp. IOPU, Nq.53 and Nq.72 drew our attention. The
sponge Iotrochoto purpurea derived Streptomyces sp. IOPU produced seven diverse
bioactive compounds: hexahydro-menaquinone MK-9 (I), linoleic acid (II), methyl
linoleate (III), borrelidin (IV), ferulic acid (V), N-acetylanthranilic acid (VI) and
sitosteryl-3β-D-glucoside (VII). The marine sediment derived Streptomyces sp. Nq.53
produced six diverse bioactive compounds: N-acetyl tryptamine (VIII), indole acetic
acid (IX), indole carboxylic acid (X), 5-(N-acetyl)-pent-2-one (XI), indole acetic acid
methyl ester (XII) and β-sitosterol-3-D-glucoside (XIII). Furthermore, Streptomyces
sp. Nq.72 isolated from Nerium oleander produce four bioactive compounds:
anthranilic acid (XIV), tryptophol (XV), gleceryl linoleate (XVI), 3-hydroxy acetyl
indole (XVII). Structures of the obtained compounds were assigned by intensive
studies of their NMR (1
H, 13C & 2D NMR) mass spectrometric means. In this study,
taxonomical characterization, and fermentation of the microbial sources, followed by
structural determination of the obtained metabolites were reported together with their
antioxidant, antimicrobial, and cytotoxic activities. The cytotoxic activities of extracts
and isolated compounds were tested against KB-3-1, KB-V1, colorectal Caco-2 and
breast MCF-7 cell lines. The antimicrobial activity was tested against a set of
microorganisms.