الفهرس 
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Abstract
Gastric cancer has become an important topic in medicine
since it is a major cause of death in both the developed and
developing countries and it is now only secondary to that of
myocardial infarction. A great majority of human cancer
(about80%-90%) are attributable to environmental factors.
However, it is not an easy task to eliminate carcinogenic cause
from the environment. While modern surgery has significantly
reduced the cancer mortality.
The prevalence of H. pylori in a random sample of the
Egyptian population is almost 80% and is higher in males than
females. The infection leads to significant changes in some
biochemical parameters depending on the immunoglobulins
present and gender. The effect of the predominance of one of the
immunoglobulins on the investigated parameters is very limited.
Helicobacter pylori infection has been established to be the
risk factor for gastric cancer .Atrophy of parietal cells causes
hypochlorohydria. The loss of the acid is then thought to allow
bacteria to overgrow in the gastric mucosa and transform nitrates
to carcinogenic N-nitrosamines. Infection related-inflammation
may be critical in disease pathogenesis. chronic inflammation has
been linked to numerous malignancies. The rapid turnover of cells
and the production of tissue oxidants by inflammatory cells both
would favor cell mutation.
Among the 80 serum samples studied, 63 were found to be
infected by H. pylori (79%). The infected samples included 30
samples IgA+IgG+, 17 IgA+IgG-, and 16 IgA-IgG+.