الفهرس 
Characteristics and functions of HCV proteinsOnly 14 pages are availabe for public view
 |  | from | 149 |  |  |
| | | from | 149 | | |
Abstract
Chronic hepatitis C virus (HCV) infection is associated with progressive liver inflammation which in turn leads to cirrhosis and finally causes hepatocellular carcinoma (HCC). By different escape mechanisms, the virus succeeds to evade the innate and acquired immune responses to establish chronic infection.
Aim: This study aimed to evaluate the level of chemokine CXCL9 and its correlation with some biochemical parameters in different subjects of HCV patients.
Materials and Methods: A total of 83 persons participated in this study including healthy individuals negative for both HCV antibodies and HCV RNA (22.9%), HCV treated responders achieved SVR after treatment, HCV antibodies positive and negative for HCV RNA after treatment (24.1%), spontaneous or natural clearance patients, with positive HCV antibodies and negative HCV RNA without treatment (26.5%) and chronic HCV-patients, with positive HCV antibodies and positive HCV RNA without treatment (26.5%). HCV RNA was quantitated by real time PCR and serum CXCL9 level was measured by commercial ELISA kit. All biochemical and hematological examinations were assessed. Results: The data showed that, the level of CXCL9 was significantly increased in chronic individuals than spontaneous clearance and responder subjects (P≤ 0.05). Furthermore, CXCL9 levels correlated variably with some biochemical and hematological parameters according to each subject. Conclusion: Serum Chemokine CXCL9 level is associated with spontaneous clearance of HCV and response to HCV treatment, which may be identified as a predictive marker in HCV patients.