الفهرس 
Acknowledgment
Pathogenesis of onychomycosisOnly 14 pages are availabe for public view
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Abstract
Onychomycosis is a fungal infection of the nail caused by der-matophytes, non dermatophytic moulds, yeasts (e.g.,Candida) or a combination of them. Onychomycosis is the most common disease of the nails worldwide and constitutes about a half of all nail abnormalities. Due to the thick keratin structure of the onychomycotic nail topical agents are not effective alone thus systemic treatment is necessary. This study was conducted over the period from February 2018 to June 2019 in Assuit University Hospital and Dermatology Clinic Assuit on 60 patients of both sex aged from 20-70 years with fingernail onychomycosis to detect the most common strains, evaluate the quality of life of these patients and to compare efficacy of three systemic antifungal agents (Fluconazole, Itraconazole and Terbinafine) on clinical and quality of life bases. Our patients age ranged from 20-70 years. 95% were females and only 5% were males. DLSO was the predominant type and Candida species were the most common detected organism among the studied patients. As regards clinical cure at the end of the study, patients treated with terbinafine showed the most significantly improved clinical cure (75%), whereas in patients treated with fluconazole and itraconazole, the clinical cure rates were 60% and 50% respectively There was highly statistically significant difference in naildex score before and after treatment in the three studied groups and there was a positive correlation between the naildex score and the duration of fungal infection.