الفهرس 
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Abstract
Gastric cancer is a major health burden worldwide. Development of gastric cancer involves host genetics, environmental factors, and H. pylori infection. There is increasing evidence from epidemiological studies of the association of H. pylori infection and specific virulence factors with gastric cancer. Studies in animal models indicate H. pylori is a primary factor in the development of gastric cancer.
One major virulence factor in H. pylori is the cytotoxin-associated gene A (cagA), which encodes the cagA protein in the cag pathogenicity island (cag PAI). Studying the association between the genotypes of H pylori virulence factors and gastric carcinoma would help selecting patients who would benefit from H. pylori eradication treatment, with a subsequent reduced risk of gastric cancer. Thus, this study aimed at studying the possible association between H. pylori virulence factor cagA and its genotypes and the development of gastric carcinoma among a cohort of Egyptian patients.
The study included 30 patients; 15 patients with GC (13 males and 2 females, mean age 54.1 ± 9.9 years), and 15 with chronic gastritis (7 males and 8 females, mean age 47.2 ±19.4 years). Patients were recruited from the National Cancer institute in Cairo and the Gastroenterology unit of the Suez Canal University hospital in Ismailia.