الفهرس | Only 14 pages are availabe for public view |
Abstract Rationale and aim of work: The present study aimed at elucidating the possible antidepressant role of some narcotic plants including Datura stramonium and Hyoscyamus muticus on the damage of the frontal lobe as compared to the antidepressant drug (Seroxat) for gestational depression on mother and offspring. Materials and Methods: After mating, plant extracts and antidepressant drug were administered daily orally from the first day of fertilization to parturition. After parturition, we sacrificed both the mothers and their offspring after one week of delivery. The frontal lobe wa” " ~ " ” excised and prepared for light microscopic study using H&E, Congo red and Serotonin transporter immunohistochemistry in addition to transmission electron microscopic observations. Results: Histopathological studies showed damaged frontal cortex in the pregnant rat. The treatment with Datura resulted in mild improvement in molecular and external granular layers but no improvement in the rest of the frontal cortex in most mothers and offsprings groups at the histological, histochemical, immunohistochemical and electron microscopic observations. In contrast, the treatment with Hyoscyamus had more improvement than Seroxat for mothers but not for offsprings |