الفهرس 
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Abstract
Background: Rosacea is a chronic disorder characterized by a variety of clinical manifestations. Four subtypes exist. Rosacea is commonly observed in individuals with Fitzpatrick skin types 1 and 2; Females over the age of 30 are most commonly affected. Ivermectin 1٪ cream is a topical anti-parasitic agent which has a therapeutic effect due to its activity against demodex mites. PDL have become a mainstay for treating PWS, facial telangiectasias, and rosacea due to their safety and efficacy. Aim of the study: the aim of this study was to provide a comprehensive clinical and dermatoscopic comparative study between the efficacy and safety of pulsed dye laser alone versus its combination with topical ivermectin 1% in the treatment of rosacea. Patients and methods: According to treatment protocol the patients were scheduled to undergo 4 laser sessions with 4 week intervals. Regarding PDL treatment, the laser parameters applied in this study were (5to7 mm spot size, a duration of 450 microsecond and a wavelength of 585 nm, 5 to 6.5 j/cm2). Results: The present study demonstrated the clinical and dermatoscopic effectiveness of both PDL and combined PDL and ivermectin 1٪ cream for the treatment of rosacea. Both groups showed high score of improvement. Moreover the combined PDL and ivermectin 1% cream was found to have a greater treatment effect than PDL alone, according to the improvement score, and satisfaction score. However, this difference wasn’t significant (p= 0.296), (p=0.341) in papular and erythema type respectively Conclusion: As regard to the combination of PDL and ivermectin 1% cream to treat rosacea in this study, we got the benefit of both in treating the patients. This was explained by the superiority of combined PDL and ivermectin 1% cream over PDL alone.