الفهرس 
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Abstract
In this study, thymoquinone and different doses of
nanothymoquinone were used as chemopreventive agents to HBP\DMBA
carcinogenesis model. The study was carried out on one hundred and
seventy male golden Syrian hamsters, which were divided into 7 groups:
group “A”: (25 animals) served as negative control and received no
treatment.
group “B”: (20 animals) positive control group. The left buccal
pouch of these animals was painted 3 times\week by the carcinogen
(DMBA).
Groups “C”, “D”, “E”, “F” and “G”:: 25 animals each were injected
with thymoquinone 0.1mg/kg, nanothymoquinone 0.1mg/kg,
nanothymoquinone 0.05mg/kg, nanothymoquinone 0.025mg/kg and
nanothymoquinone 0.01mg/kg respectively dissolved in propylene glycol
daily in the first two weeks. This was followed by combined treatment with
DMBA and the preventive agents 3 times\week for 6 weeks. All animals
were left untreated for further 2 weeks.
Two blood samples were withdrawn from three animals in each
group every two weeks, one considered for complete blood count analysis
(CBC), and a serum sample for liver and kidney enzymes analysis. The
results were then tabulated and statistically analyzed.
The treated left pouches and the untreated right pouches were
surgically excised, fixed, and processed for H&E stain.