الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study aimed to demonstrate the possible role of nicorandil on glycemic
state and vascular reactivity in diabetic rats.
Fifty male albino rats of local strain, weighing (200-250) grams each were used in
this work. The animals were classified into the following groups:
(I)Non-diabetic group.
(II) Diabetic non treated group.
(III)Diabetic insulin-treated group.
(IV)Diabetic nicorandil-treated group.
(V) Diabetic insulin and nicorandil treated group.
At the end of the experiment (8 weeks) each group was subjected to the following
parameters:
1. Laboratory tests: fasting glucose level and glycosylated hemoglobin.
2. Measurement of arterial blood pressure and in vivo vascular reactivity.
The results of this study showed that induction of diabetes mellitus by
streptozotocin was associated with a significant increase of fasting serum glucose,
glycosylated hemoglobin, arterial blood pressure, and a significant decrease of
vascular reactivity to all doses of vasoconstrictors and vasodilators, when compared
with the corresponding values in the diabetic non treated group.
In the present work, insulin treatment resulted in a significant decrease in
fasting serum glucose, arterial blood pressure, and a significant increase of vascular
reactivity to all doses of vasoconstrictors and vasodilators, when compared with the
corresponding values in the non-diabetic control group.
In the present study, Nicorandil therapy resulted in no significant change of
fasting serum glucose and glycosylated hemoglobin when compared with the
corresponding values in the diabetic non treated group. But showed a significant
decrease in arterial blood pressure and a significant increase of vascular reactivity to
all doses of vasoconstrictors and vasodilators, when compared with the corresponding
values in the diabetic non treated group.
In the diabetic combined insulin and nicorandil treated group, there was a
significant decrease of fasting serum glucose, glycosylated hemoglobin, when
compared with the corresponding values in the diabetic non treated group, and
insignificant when compared with the diabetic insulin-treated group. Also, there was
a significant decrease of arterial blood pressure and a significant increase of vascular
reactivity to all doses vasoconstrictors and vasodilators, when compared with the
corresponding values in the diabetic non treated group and insignificant when
compared with the corresponding values in the control group.