الفهرس 
Introduction And RationaleOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most common cancer and the second leading cause of cancer death in women. It is a heterogeneous neoplasm having various subtypes with substantial differences in biology and diverse clinical outcomes.
The discovery of numerous non-coding RNAs has dramatically changed our understanding of cell biology, especially the pathophysiology of cancer. Several studies revealed that Long non-coding RNAs (lncRNAs>200 nucleotides) are considered as key regulators of gene expression, cell biology and carcinogenesis and dysregulation of their expression levels are associated with cancer initiation, progression, and metastases. Recently lncRNAs have a great potential to consider them as novel prognostic biomarkers as well as new therapeutic targets in many types of cancer.
In 2010, long intergenic non-coding RNA, regulator of reprogramming (Linc-ROR) was discovered. It regulates many target genes involved in tumorgenesis through controlling different signaling pathways. Linc-ROR is an oncogene that stimulates proliferation, invasion and metastasis in breast cancer through different complex pathways.
So, this study was conducted to determine the expression levels of linc-ROR gene in the blood of a group of Egyptian breast cancer female patients and to correlate its expression level with clinical and pathological features of breast cancer for future using as a non invasive and potential biomarker for the diagnosis and dynamic monitoring of breast cancer