الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
In this retrospective comparative case series, we compared the outcomes of single iStent vs. double iStent inject implantation combined with phacoemulsification in open angle glaucoma at 6 and 12 months. The efficacy and safety of the first and second generation iStent have been extensively studied either standalone or combined with phacoemulsification. However, the literature comparing both devices is relatively limited, and the results are not conclusive. In this study we included a relatively large sample size (n=197), compared both devices using different criteria, and identified predictors for surgical failure using univariate and multivariate regression analyses. The results showed favorable iStent inject outcomes vs. iStent in terms of lower IOP at month 6 (P = 0.003), higher proportion of eyes with IOP ≤ 15 mmHg at month 6 (P = 0.003) and month 12 (P = 0.047). However, surgical success defined as 20% IOP reduction from baseline was comparable in both groups at month 6 (P = 0.240) and month 12 (P = 0.875).Kaplan-Meier survival analysis comparing surgical failure rates at 1-year follow-up revealed no difference between both groups (P = 0.644). Multivariate regression model (P < 0.001) demonstrated that older age (P =0.017) and lower baseline IOP (P = 0.002) were the strongest predictors of surgical failure at month 12. Sex, race, glaucoma type, and surgery type were not significant predictors of failure. Additional analysis of surgical success based on the proportion of eyes that achieved target IOP according to the glaucoma severity showed that surgical success increased from 47.5% to 94.3% in the iStent group and from 50.0% to 95.0% of the iStent inject group.