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العنوان
Synthesis of Some New Derivatives of 2-Mercaptobenzimidazole with Expected
Biological Activity /
المؤلف
Salama, Wafaa Mohamed Abd El ghafar
هيئة الاعداد
باحث / وفاء محمد عبد الغفار سلامه
مشرف / ابراهيم فتحي زيد
مناقش / محمد حسين مصطفي
مناقش / أحمد ابراهيم خضير
الموضوع
Structural Properties of 1,2,4-Triazole derivatives Dedicate Abbreviations.
تاريخ النشر
2020.
عدد الصفحات
216 P :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
تاريخ الإجازة
15/11/2020
مكان الإجازة
جامعة المنوفية - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

from 273

from 273

Abstract

Triazole and tetrazole analogues play an important role in medicinal and
bioorganic chemistry owing to their antimicrobial, antifungal, anticancer,
and anti-inflammatory activities. O-Phenylenediamine (1) was reacted
with carbon disulphide and potassium hydroxide to afford the
corresponding 2-mercaptobenzimidazole (2), which reacted with dimethyl
sulphate and potassiumhydroxide to give 2-(methylthio)-1Hbenzo[d]imidazole (3). The compound 3 was reacted with hydrazine
hydrate to give the corresponding hydrazide 4. Hydrazide 4 was reacted
with acetic acid to give triazole derivative 5. The triazole 5 was reacted
with acrylonitrile to afford 2-(3-methyl-1H-benzo[4,5]imidazo[2,1-
c][1,2,4]triazol-1-yl)acetonitrile (6).