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العنوان
Mirabegron for treatment of erectile dysfunction in patients with LUTS secondary to BPH :
المؤلف
El-Baz, Ramy Farag.
هيئة الاعداد
باحث / رامى فرج الباز
مشرف / أحمد عبدالرحمن شقير
مشرف / أحمد محمد العاصمى
مشرف / محمد حسن زهران
مناقش / بدير على الدين حسن
مناقش / أحمد ابراهيم السقا
الموضوع
Urology. Prostatic Hyperplasia.
تاريخ النشر
2021.
عدد الصفحات
online resource (83 pages) :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
جراحة المسالك البولية
تاريخ الإجازة
28/2/2021
مكان الإجازة
جامعة المنصورة - كلية الطب - قسم المسالك البولية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Back ground: Erectile dysfunction (ED) is a major world-wide problem, it is associated with many urological diseases including benign prostatic hyperplasia(BPH) (Gonzalgo et al., 2003). Of patients developed histologic BPH, 30-50% will develop bothering lower urinary tract symptoms (LUTS). Medical treatment of LUTS/BPH can adversely affect erectile and ejaculatory functions (Narayan and Lepor, 2001). A recent study by Gur et al (Gur et al., 2016) investigated the effect of mirabegron on HCC in vitro and showed marked relaxation of HCC by activating B3-adrenoceptors independently of nitric oxide (NO) pathway. Aim of the work: To assess the efficacy of mirabegron in treatment of erectile dysfunction (ED) concomitant with lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). Patients: In this randomized controlled trial (RCT), 61 sexually active LUTS/BPH patients with concomitant ED were assessed for eligibility. Methods: patients were randomly allocated in two groups: the first received mirabegron 50 mg plus doxazosin 2 mg once daily (mirabegron group) and the second one received tolterodine 4 mg plus doxazosin 2 mg (tolterodine group) for 12 weeks. The evaluation was based on International Index of Erectile Function (IIEF-15) questionnaire, Erection Hardness Score (EHS) questionnaire, International Prostate Symptom Score (IPSS), quality of life (QoL), uroflowmetry and post voiding residual (PVR). The therapeutic outcomes were assessed at 4, and 12 weeks compared to the baseline. Results and conclusion: Only, mirabegron group achieved significant improvement in sexual functions including IIEF total score, its erectile function domain and EHS after 4 and 12 weeks. Regarding the urinary characteristics, both groups showed significant improvement in urinary characteristics. So, mirabegron may be potential useful drug for treatment of ED. Recommendations: more studies with big number of patients are needed.