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Abstract Food additives are natural or synthetic chemicals added to food to preserve flavor, enhance its texture or appearance, or for other technological functions. Food additives are among the safest chemicals in food due to their low toxicity, rigorous safety testing, and control of use by the law. The permission to use specific food additives is recommended by the Codex Alimentarius Commission and approved by national legislation. The use of food additives is subject to strict controls, underpinned by scientific studies to demonstrate their safety to human health. Their use brings many benefits including increased safety, and greater choice of food products. However, although consumers were aware of the benefits additives could deliver, the automatic assumption that additives were ‘bad’ remained and consumers felt that additives should be reduced in foods. This study aims at the effect of feeding on different levels of food additives and their effect on both body weight and feeding efficiency of rats fed 1% tomato flavor and cheese flavor and 10% chips with the above flavors The weight of the organs of mice fed on cheese flavor 1% and tomato flavor 10 % Of flavored potatoes with cheese and tomato flavor. Liver function, fat, kidney function, and blood glucose for rats fed 1% cheese flavor, tomato flavor and 10% tomato and cheese flavored chips. Pathological histological composition of the liver, stomach and brain of rats fed a diet with 1% cheese flavor, tomato flavor and 10% tomato and cheese flavored chips. To achieve aims, the design of the study were as follows Thirty adult female albino rats, weighting (115±5g) were used in present study. All rats were fed standard diet for 7 days for adaptation. Rats are divided into 5 groups, each group which consists of 6 rats as follows: group )1( : Rats fed on basal diet as control group. group )2(: Rats fed on basal diet with 10% product 1 ( chips with tomato flavor ). group )3(: Rats fed on basal diet with 10 % of product 2 (chips with cheese flavor). group )4 (: Rats fed on basal diet with 1% chips with tomato flavor. group )5( : Rats fed on basal diet with 1% chips with cheese flavor. At the end of experimental period (60 days), rats were sacrificed after 12h of fasting, blood samples were collected from the hepatic portal vein to separate the serum by centrifugation and kept it at a temperature of -20 ° C until used it to estimate the following analyzes: Blood glucose (estimated it at the beginning, middle and last of experimental period), insulin levels, HbA1c, kidney function (Creat , urea, total protein and Uric acid), lipid profile (TC, TG, HDL-c, LDL-c and VLDL-c), liver function ( AST, ALT and ALP), and hematological parameters ( Hemoglobin, RBCs, MCV, MCH, WBCs, Lymphocytes and Haematocrit ). |