الفهرس 
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Abstract
Breast cancer is a heterogeneous disease, it has been classified into different histologic types. In addition, breast cancer is classified into intrinsic molecular subtypes by gene expression profiling namely Luminal-A, Luminal-B, HER-2 enriched, and triple negative breast cancers. Each of these has a variable incidence, risk factors, prognosis and sensitivity to treatment.
Invasive ductal carcinoma (IDC) of no special type or not otherwise specified (NOS) is the most common (40–75%) histologic type of invasive breast cancer. IDC NOS is not at all well defined, and the 2012 World Health Organization (WHO) classification defines IDC NOS by exclusion, as “the heterogeneous group of tumors that fail to exhibit sufficient characteristics to achieve classification as a specific histological type.
New prognostic markers such as p27 (Kip I) and Cyclin D1 are becoming valuable tools for the prediction of prognosis and survival outcomes in women with breast cancer.
Aim: This work aimed at studying the expression of p27 and Cyclin D1 in breast duct carcinoma in correlation with clinicopathological parameters and prognostic factors in breast cancer, including estrogen receptor and progesterone receptor status, and HER2/neu expression.
Materials and methods: The present work studied the immunohistochemical expression of Cyclin D1 and P27 in invasive ductal carcinoma of the breast in correlation with clinicopathological parameters and prognostic factors in breast cancer including estrogen receptor, progesterone receptor status and HER2/neu expression.
Results: 7 cases showed strong immunohistochemical expression of cyclin D1, 33 cases showed weak immunohistochemical expression of cyclin D1, 10 cases showed negative expression of cyclin D1.
18 cases showed high immunohistochemical expression of P27, 20 cases showed low immunohistochemical expression of P27, 12 cases showed negative expression of P27.
There was a statistically significant result between cyclin D1-, cyclin D1+ and cyclin D1++ cases as regards tumor size, axillary lymph node metastasis, ER status, PR status, Her 2 status and subtypes according to hormone receptors / Her 2 status.
There was no statistically significant result between cyclin D1-, cyclin D1+ and cyclin D1++ cases as regards vascular invasion, histologic grade and age.
There was a statistically significant result between P27 negative, P27 weak positive, and P27 high positive cases as regards tumor size, histologic grade, ER status, PR status, Her 2 status and subtypes according to hormone receptors / Her 2 status.
There was no statistically significant result between P27 negative, P27 weak positive, and P27 high positive cases as regards axillary lymph node metastasis, vascular invasion, and age.
There was a statistically significant association of Cyclin D1 overexpression and high expression of p27 in invasive ductal carcinoma.
Conclusion: Positive expression of cyclin D1 and P27 suggests good prognosis, and can be used in the evaluation of prognosis of breast cancer.