الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
DR still remains the world’s leading cause of visual disability and blindness. It has been categorized as NPDR and PDR. NPDR is subclassified as mild, mild and severe. In the early phases, it is asymptomatic, but concludes with visual loss.
DME is the existence of retinal thickening in the vision center and can lead to vision blurring and distortion. At any stage of DR, it may happen.
DMI it is a complication of DR characterized by enlargement of the FAZ, located at the center of macula, along with perifoveal capillary dropout
Spectral-domain OCTA is a new modality that shows retinal microvasculature with a resolution that surpass fluorescein angiography (FA) securely, rapidly and noninvasively.
The aim of this work was to study the ability of OCTA to detect and analyze retinal microvasculature changes in early diabetic retinopathy compared to FA.
This study included total of 40 eyes of 21 patients with NPDR with and without DME, who presented to the ophthalmology department outpatient clinic at Alexandria Main University Hospital. A control group of 20 normal eyes was included.
The ability of OCTA to detect MAs is limited compared with FA as the number of MAs was more evident with FA more than OCTA. When comparing between FA and OCTA (SCP and DCP) in regard to number of MAs, there was a highly statistically significant differences between them were P <0.001 in all cases.
Morphological appearance of FAZ was identical between FA and SCP layer by OCTA. FAZ area was analysed by OCTA, and when correlating between the 3 groups, results showed that the FAZ size in the control group is far too small than in the other groups of eyes with NPDR with and without DME.
DMI was analyzed using OCTA, that studied macular CP and vessel density in NPDR eyes with and without DME and then both groups were correlated with the normal eyes. The results concluded that macular capillary perfusion percentage and vessel density decreases early in DRP patients. However, there was only mild non significant difference between eyes with and without DME, therefore DME does not seem to affect the macular capillary perfusion and the macular vessel density.