الفهرس 
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Abstract
The present work was performed to study the role of vitamin D on some brain degenerative disorders in male albino rats. . The present work was carried out on 40 Wistar male albino rats. The rats were divided into three groups. group I : (Control group) (10 rats) These animals received intraperitoneal (ip) injection of 1ml normal saline once daily for two consecutive weeks followed by intramuscular (im) injection of 0.01ml corn oil for two weeks. group II : (AlCl3 treated group) (10 rats) These animals received ip injection of aluminum chloride (AlCl3) at a dose of 7 mg/kg body weight once daily for two consecutive weeks followed by im injection of 0.01ml corn oil for two weeks . group III: (VD3 treated group): (20 rats) The animals of this group were subdivided into: group III a:( 10 rats) These animals were received im injection of VD3 at a dose of 1μg/kg once daily for 7 days followed by injection of both AlCl3 at a dose of 7 mg/kg body weight and the same dose of VD3 for two weeks then rats were received ip injection of 1ml normal saline once daily for one week . group III b : (10 rats) These animals were received ip injection of AlCl3 at a dose of 7 mg/kg body weight once daily for two consecutive weeks followed by im injection of VD3 at a dose of 1μg/kg once daily for two weeks . At the end of experimental period all the animals from all groups were subjected for: I- Behavioral tests: • Locomotor Activity Test (Open field test) • Forced swimming test • T-maze test II-Tissue sample preparation: After anesthetization by ip injection of pentobarbital, animals were sacrificed and the brains were immediately removed, placed in ice- cold isotonic saline and cerebrum was dissected , then stored at −80 oC. Later the brain regions were taken and minced into small pieces then homogenized to yield the supernatant which later used for the estimation the following parameters: • Acetylcholinesterase (AChE) • Malondialdehyde (MDA) • Glutathione Peroxidase (Gpx) The results of the present work revealed the following: AlCl3 treated group: There was significant decrease in AChE, Gpx, locomotion and the time animals remain in enclosed arm in test session and re test session as compared to control group. However there was significant increase in MDA, immobility time in forced swimming test, the time when animals remain in enclosed arm in trial 1, 2, 3 and in number of trials to reach avoidance criterion as compared to control group. VD3 treated group: There was significant increase in AChE, Gpx, locomotion and the time animals remain in enclosed arm in test session and re test session as compared to AlCl3 treated group. However there was significant decrease in MDA, immobility time in forced swimming test, the time when animals remain in enclosed arm in trial 1, 2, 3 and in number of trials to reach avoidance criterion as compared to AlCl3 treated group. group III b vs III a: There was significant decrease in AChE, Gpx, locomotion and the time animals remain in enclosed arm in test session and retest session in group IIIb as compared to group III a. However there was significant increase in MDA, immobility time in forced swimming test, the time when animals remain in enclosed arm in trial 1, 2, 3 and in number of trials to reach avoidance criterion in this group as compared to group IIIa. Conclusions: We can concluded that either the protective or the therapeutic effect of vitamin D produced significant improvement in motor impairment, learning and memory through its antioxidant effect and increased level of Ach E activity , although the protective effect was more significant than that of the therapeutic effect . These findings should stimulate translational research towards the VD3 potential for prevention or treatment of neurodegenerative diseases. Recommendation: We recommend further studies on the therapeutic effect of vitamin D either by increasing the dose or the duration of the treatment.