الفهرس 
Aim of workOnly 14 pages are availabe for public view
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Abstract
This study was conducted on 250 (two hundred and fifty) clarias gariepinus with an average weight of 90 ± 10 grams per fish to investigate the effects of MgO and MnO nanoparticles supplementation on the blood lipids (triglycerides and cholesterol), kidney functions (creatinine and urea), liver functions (ALT – AST - ALP - LDH), antioxidants (CAT – SOD - GPx) and body performance (body weight and weight gain). Samples were collected on day 15, 30, 45 and 60 from the starting point of the experiment.
The study was designed by dividing the fish into 5 groups to achieve the planned objectives:
group 1: (Control Group): Fish were fed on basic rations according to NRC.
group 2: fish were fed on the basic ration with 0.04 mg magnesium oxide nanoparticles / kg ration instead of 0.04 mg magnesium sulfate / kg ration. (MgO-d group received full dose)
group 3: fish were fed on the basic ration with 0.02 mg magnesium oxide nanoparticles / kg ration instead of 0.04 mg magnesium sulfate / kg ration. (MgO-hd group received half dose)
group 4: Fish were fed on the basic ration with 2.4 mg manganese oxide nanoparticles / kg ration instead of 2.4 mg manganese oxide / kg ration. (MnO-d group received full dose)
group 5: Fish were fed on the basic ration with 1.2 mg manganese oxide nanoparticles / kg ration instead of 2.4 mg manganese oxide / kg ration. (MnO-hd group received half dose)
The results of this study indicated that the 3rd and the 5th groups exhibited a significant decrease in triglycerides and cholesterol on determination of blood lipid profile at the day 60 of the study compared to the other treated groups and the control group. Also, the two groups appeared the best results in liver function tests with significantly decreased levels of ALT - AST - ALP – LDH enzymes and kidney function tests with significantly decreased levels of creatinine and urea compared to the other treated groups and the control group. Shifting to the antioxidants, these two groups showed a significant increase in CAT, SOD and GPx levels in the serum compared to the other treated groups and the control group at day 60 of the experiment.
The findings of this investigation bring to light that the 2nd and the 4th groups gave significant decrease in triglycerides and cholesterol on determination of blood lipid profile at the day 60 only of this study compared to the control group. These two groups showed insignificant decrease in liver enzymes (ALT - AST - ALP - LDH) and kidney function tests (creatinine and urea) compared to the other treated groups and the control group. Referring to the antioxidants, these two groups appeared insignificant increase in serum CAT, SOD and GPx levels compared to the control group at day 60 of the experiment.
Concerning the results of body performance, the second, third, fourth and fifth groups reflected a significant improvement in body weight and weight gain compared to the control group. Finally, the 3rd and 5th groups exhibited the highest final body weight and weight gain compared to 2nd, 4th and control groups.
In conclusion, The results of this study referred to the Magnesium oxide nanoparticles at a concentration of 0.02 mg/kg and Manganese oxide nanoparticles at 1.2 mg/kg in ration significantly boosted the blood lipids profile of Clarias gariepinus fish including triglycerides and cholesterol, augment the kidney (Creatinine and Urea) and liver functions (ALT, AST,, ALP and LDH), improved antioxidant capacity (CAT, SOD and GPx) and enhanced the body performance including body weight and body gain of the treated fish.