الفهرس 
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Abstract
Mental illnesses and substance use are highly prevalent impairments that frequently co-occur. The presence of a substance use is accompanied with at least a two fold increase in risk of fulfilling the criteria for another psychiatric illness, and this may be a sum of multiple factors affecting the patients as a general and mainly adolescents; including sociodemographic style, family history of substance use or mental illnesses, and the mental health service availability. Many recommendations aimed to explain the connection between comorbid psychopathology of mental illnesses and substance use. These may include: that patients with psychiatric disorders may try to alleviate their ego dystonic discomfort by self-medicating with substances leading to a problematic use of the substances, that the substance use could lead to major psychiatric illness , that certain individuals might have a genetic predisposition to either mental illness and/or substance use resulting in comorbidity conditions, that either condition could interfere, or effect a change in the course of the other condition, that the substance use and psychopathology share a common neurons. In evaluating the connection between use of certain substances and concurrent disorders there is evidence that internalizing disorders may be more commonly associated with monosubstance use, while externalizing disorders are associated with polysubstance use. This comorbidity is highly prevalent among adolescents and ranges from 20% to 33%, with predominance in males and elder adolescents, and there is often comorbid poly substance use in patients with mental illness and particularly psychosis.