الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 83 |  |  |
| | | from | 83 | | |
Abstract
Preeclampsia is a syndrome diagnosed by hypertension and proteinuria after 20 weeks of gestation; it affects 5–10% of all pregnancies and remains a leading cause of maternal and fetal morbidity and mortality. Based on clinical presentation, preeclampsia is considered as a late pregnancy disorder, but the molecular events leading to its onset seem to occur early in pregnancy. Maternal symptoms of preeclampsia are considered consequences of placental pathology associated with poor placental perfusion, inflammation and ischemia / hypoxia and trophoblast damage.
This study was designed to study the serum level of C3, C4, and CRP level in severe and mild preeclampsia and normotensive pregnant women at third trimester and to correlate level of those parameters with severity of preeclampsia, fetal and maternal outcome.
The patients were recruited from El-Shatby Maternity University Hospital. They were divided into three groups, group (I): thirty-five severe preeclampsia patients, group (II): thirty-five mild preeclampsia patients and group (III): thirty five normal pregnant women.
All patients (n=105) underwent complete history taking, clinical examination, ultrasound examination for fetal biometry, mean gestational age, amount of liquor, and estimate fetal weight by ultrasound.
Laboratory investigations were carried out including complete blood count, liver function tests, renal function tests, and serum level of C3, C4, and CRP.
The results showed that there was no statistically significant difference as regards age, and gravidity& parity but there was statistical significant among the studied groups regarding the gestational age.
Severe preeclampsia group had significantly higher number and percentage of IUGR than normal group but there was no statistically significant difference between mild preeclampsia and normal group.
The mean for maternal serum level of C3 and C4 in severe preeclampsia group was significantly high in comparison to normotensive group and mild preeclampsia group. Also, there were statistically significant difference mild preeclampsia groups and normotensive groups.
There was no correlation and statistical significance between C3, C4, CRP levels and systolic blood pressure or diastolic blood pressure.
There was correlation and statistical significance between C3and maternal outcomes while on correlation with C4 CRP in severe preeclampsia group, but there was no correlation and statistical significance between C3, C4, and CRP with fetal outcome in severe preeclampsia.