الفهرس 
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Abstract
Psoriasis is a common chronic inflammatory disease of the skin and joints, affecting 2–4% of the population worldwide . Psoriasis is characterized by an exaggerated proliferation of keratinocytes secondary to an activated immune system.
Psoriasis is a systemic, relapsing and hyper-proliferative immune- mediated skin disorder. PS results from interaction between genetic predisposition and large spectrum of environmental factors that triggers the development of skin lesion. T-helper 1 and Th 17 mediated inflammation have been proposed to be pathologically essential in psoriasis
Environmental, genetic, and immunologic factors appear to play a role. The disease most commonly manifests on the skin of the elbows, knees, scalp, lumbosacral areas, inter-gluteal clefts, and glans penis. In up to 30% of patients, the joints are also affected.
Osteopontin is O-glycosylated phosphoprotein that is synthesized in a various of tissues and cells and secreted into body fluids. It was originally identified as a bone matrix protein and subsequently identified as a cytokine produced by activated T cell and is classified as a Th1 cytokine because it modulates cell-mediated immunity by promoting Th1 response.
OPN exists in two distinct isoforns: secreted osteopontin (sOPN) which is expressed in various tissues as bone, mammary glands , brain and the immune organs . And/or intracellular osteopontin (iOPN) that’s expressed in dendritic Cells and macrophages
The aim of the current study was to evaluate serum level of OPN status of psoriasis patients. This case-control study included 40 psoriasis patients
(Patient group) and 40 apparently healthy subjects served as a control group with matched age and sex. The study was done in the department of Dermatology and Andrology Faculty of Medicine Beni-Suef University.
The patients were selected from the outpatient clinics of Beni-Suef university hospitals. Healthy population were recruited from the partners or relatives of patients if not affected by psoriasis in order to minimize the difference.
For every patient included in the study , the following items were fulfilled: detailed history, general physical examination, complete dermatological examination. Psoriasis-related variables included disease duration and severity according to the psoriasis area and severity index(PASI) and the presence of psoriatic arthritis. Laboratory investigations included measurement of OPN levels in serum using commercial ELISA kits.
There was no correlation between PASI and serum level of OPN. And, there was no significant difference between psoriasis cases and control group regarding serum OPN
There was no statistically significant difference between the studied groups as regard age or sex. And there was no significant relation between psoriasis severity and serum OPN level.