الفهرس 
SepsisOnly 14 pages are availabe for public view
 |  | from | 115 |  |  |
| | | from | 115 | | |
Abstract
Background:
Septic shock is one of the most common causes of admission to the intensive care unit in the world and one of the most common causes of death among intensive care patients. Since the definition of sepsis and septic shock and many studies have been designed to understand everything about sepsis regarding mechanism, pathophysiology, complications, diagnosis, management and all other aspects.
Overall mortality in patients with septic shock is decreasing and now averages 30 to 40% (range 10 to 90%, depending on patient characteristics). Poor outcomes often follow failure to institute early aggressive therapy (eg, within 6 h of suspected diagnosis). Once severe lactic acidosis with decompensated metabolic acidosis becomes established, especially in conjunction with multiorgan failure, septic shock is likely to be irreversible and fatal.
One important aspect which is diagnosis was the target for many studies as it is always challenging ,even with all the available facilities, to make a diagnosis for intensive care patients and to start the management accordingly. The more important issue other than starting a management plan is to modify it when needed and know when we should change our plan and how we should do that. So, sepsis markers was specifically studied thoroughly and many sepsis marker has been introduced since the definition of sepsis till now but every marker with different role, sensitivity and specificity. There are markers which can be used to guide our management plan for septic shock patients, predict mortality and even modify the whole plan totally. Two more challenging things for the markers which were the cost and the availability of the marker. So,we focused here to find an available and relatively cheap marker to help us in the management and to predict mortality. The related death should be investigated more thoroughly and distinguished to early and late death because it may carry different mechanisms. In this study we classified the patient to early, late and survival classes and studied the relation between those groups and neutrophil to lymphocyte count ratio regarding mortality. Many sepsis markers are readily available in the laboratories but the expenses of the laboratory investigations are always a major hinder the we all face in our daily practice. NLCR is a readily easy ratio we can calculate from full blood count that in nearly drawn in every critically ill patients in ICU like the patient of septic shock. So our major role in this study is to find if there is a clear relation between this ratio and the prognosis of septic shock patient and if we can predict the mortality of those patients with such more cheap and readily available tool.