الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Ehrlich ascites carcinoma (EAC) can be also categorized as an indistinguishable carcinoma with a high transplantable capability, noregression, rapid proliferation, shorter lifespan and 100% malignancy. However, two forms of Ehrlich models are used and they are solid tumors produced by injection subcutaneous for tumor cells or ascetic tumor formation by injection intraperitoneal for these cells. Diabetes mellitus (DM) is a global health problem with chronic hyperglycemia due to impairement of insulin secretion or function. More than 220 million people worldwide have diabetes and is projected to
double or more by 2030. People with diebetic disease are usually suffered from hyperglycemia, hyperlipidemia, hypertension, atherosclerosis, retinopathy, neuropathy and nephropathy. Acridine is a nitrogen structure containing heterocyclic compounds which have numerous biological activities including antitumor, anticancer, anti-inflammatory, and antioxidant. To our knowledge, there was no
previous studies had illustrated the antitumor or anti-diabetic activities of 9-Diaminoacridine on EAC-bearing mice and STZ-diabetic mice. Therefore, the present study aimed to demonstrate the protective role of vitamin 9-Diaminoacridine against Ehrlich ascites carcinoma induced splenic tissue injury. Also, our study aimed to show the effect of 9- Diaminoacridine against streptozotocin induced pancreatic biochemical, histopathological, and immunohistochemical alterations.