الفهرس 
ContentsOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer is one of the leading causes of cancer related deaths world wide. Microorganisms are found to be either etiological agents or play a prominent role in the etiology of many cancer by two mechanisms: inflammation and/or formation of carcinogenic metabolites. Streptococcus bovis is part of the normal flora of the human alimentary tract. It was found to be actively engaged in trigerring severe inflammatory reactions in colorectal mucosa, inducing inflammatory and angiogenic cytokines leading to the formation of free radicals that are implicated in development of all types of human cancer. The study aimed to: 1. Detect prevelance of S. bovis in colorectal cancer tissues of patients attending Mansoura University for colonoscopy and the correlation with the endoscopic finding. 2. Detect risk factors for aquisation of S. bovis. This case control study was conducted at gastrointestinal Surgery Center and Microbiology Department, Faculty of Medicine. The study included 48 cases for whom colonoscopy was performed before administration of chemotherapy and 48 controls whom did colonoscopy for any reason other than colorectal cancer. All included participant in the study were subjected to: 1. Collecting their demographic data. 2. Clinical examination to detect signs of cancer colon. 3. Colonoscopy and biopsy for histopathological examination. 4. Microbiological examination for isolation and identification of S. bovis. The study resuts are: S. bovis on the surface was positive in 64.6% of cases, versus only 18.8% of controls. In tissues 17 cases showed positivity (35.4%) compared to 3 controls (6.2%).