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العنوان
Extent and severity of coronary artery disease as predictors of myocardial reperfusion in acute coronary syndrome /
المؤلف
Hemeda , Asem Abdallah Abdalaleem .
هيئة الاعداد
باحث / عاصم عبد الله عبد العليم
مشرف / عبد الله مصطفي كمال
مشرف / نجلاء فهيم احمد
الموضوع
Coronary heart disease. Acute Coronary Syndrome therapy. Myocardial infarction.
تاريخ النشر
2021.
عدد الصفحات
134 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
أمراض القلب والطب القلب والأوعية الدموية
تاريخ الإجازة
7/3/2021
مكان الإجازة
جامعة المنوفية - كلية الطب - أمراض القلب و الاوعية الدموية
الفهرس
Only 14 pages are availabe for public view

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from 145

Abstract

Acute coronary syndrome (ACS) describes a spectrum of clinical conditions ranging from ST segment elevation myocardial infarction (MI) to non-ST segment elevation MI and unstable angina (ACS without enzyme or marker release). ACS ranges from unstable angina without detectable myocyte necrosis to extensive myocardial infarction (MI). Unstable angina is characterized by the clinical syndrome, undetectable markers (troponin and CK-MB) but with ECG changes (typically ST depression or T wave inversion or transient ST elevation): the risk of death from hospitalization to six months is approximately 5–8%. Markers are elevated in acute MI in proportion to the extent of myocyte necrosis. For those hospitalized alive, the risk of death is 12–15% in the following six months (GRACE registry data). A spectrum of left ventricular dysfunction exists across ACS ranging from no measurable dysfunction to remodeling, dilatation of the ventricle, and severe systolic dysfunction [143]
We aimed in this study to assess the extent and severity of coronary artery disease as predictors of myocardial reperfusion in acute coronary syndrome.  Patients and methods In this study, 250 patients with the diagnosis of the first-time acute coronary syndrome were included. The patients were then divided into two groups according to STEMI or NSTEMI (NSTEMI and UA):  group (I): included 130 patients with STEMI in whom primary PCI done or pharmaco-invasive therapy either total or subtotal revascularization. .  group (II): included 120 patients with (NSTEMI and UA) in whom PCI done either total or subtotal revascularization.
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SummaryThe comparison was done in each two groups regarding:  Baseline characteristics.  Risk factors and co-morbidities.  ECG changes.  Cardiac Enzymes level.  Echocardiographic findings.  Coronary angiography findings extent , severity of CAD and if total revascularization or not.
 Myocardial perfusion imaging after 6-12 month to evaluate the myocardial perfusion in condition that patient not complain of any cardiac symptoms.
 Results There was highly statistically significant Association between syntax score and Myocardial perfusion imaging after 3 months (P-value = 0.000). Also, there was highly statistically significant Association between extent of CAD one vessel disease and multivessel disease and Myocardial perfusion imaging after 3 months.
There was statistically significant Association between both total revascularization and severity of Coronary artery lesion sub-total or total occlusion and myocardial perfusion imaging after 3 months.
 Conclusion
Our study indicated that there is a significant Association between both syntax score and extent of CAD and Myocardial perfusion.