Author: El safty, Mohamed Saad Mohamed Ahmed./ Title: Evaluation of T-cell immunoglobulin mucin 3 (TIM3) as ahighly sensitive minimal residual disease (MRD) monitoring strategy to predict relapse after Bone Marrow Transplant/

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العنوان

Evaluation of T-cell immunoglobulin mucin 3 (TIM3) as ahighly sensitive minimal residual disease (MRD) monitoring strategy to predict relapse after Bone Marrow Transplant/

المؤلف

El safty, Mohamed Saad Mohamed Ahmed.

هيئة الاعداد

باحث / Mohamed Saad Mohamed Ahmed El safty

مشرف / Mohamed Osman Azzazi Almessery

مشرف / Nermeen Adel Nabeeh Abdelghafar

مشرف / Rasha Kamel Fathy Galal

تاريخ النشر

2021.

عدد الصفحات

119 p. :

اللغة

الإنجليزية

الدرجة

ماجستير

التخصص

أمراض الدم

تاريخ الإجازة

1/1/2021

مكان الإجازة

جامعة عين شمس - كلية الطب - امراض الدم

الفهرس

Only 14 pages are availabe for public view

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Abstract

Disease recurrence is a devastating event after allogeneic hematopoietic stem cell transplantation as treatment for acute leukemia. Median time to relapse is approximately 4 months and the majority of relapses occur within 2 years after transplant. The prognosis is usually poor. Overall 5-year survival of all patients relapsing post-transplant for acute leukemia
Evaluation of TIM-3 level is highly monitoring strategy used as minimal residual disease to predict relapse post bone marrow transplant.
TIM-3 level post BMT has significant relation with over-all survival and disease free survival in cases of acute leukemia post allograft.