الفهرس 
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Abstract
Liver steatosis may predispose the liver to inflammation, fibrosis, and eventually cirrhosis and hepatocellular carcinoma.
Non Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent form of chronic liver disease worldwide, affecting as much as 30% of the adult western population.
NAFLD is considered as the most prevalent chronic liver disease, affecting as much as 30% of the adult western population.
NAFLD is strongly associated with metabolic risk factors such cardiovascular disease, obesity, diabetes mellitus and dyslipidemia.
Liver biopsy is the gold standard for diagnosis and quantification of liver steatosis in NAFLD; however, it is not routinely performed in all NAFLD patients because it is an invasive procedure with potential complications and a significant degree of sampling error.
Therefore noninvasive methods including imaging techniques and blood test based markers have been developed to qualify and quantify liver steatosis.
Sonographic screening of NAFLD depending on sonographic criteria as attenuation of image, diffuse echogenicity, uniform heterogenous liver, thick subcutaneous depth and enlarged liver filling the entire filed were shown to be valuable in detection of steatosis correlated to liver biopsy findings.
Hepatorenal index is another non-invasive sonographic criteria has been validated versus liver biopsy findings and could be considered as reference non-invasive method for detection of steatosis.
Excess lipid accumulation is closely related to the development of insulin resistance and NAFLD. This excess fat tissue is involved in production and metabolism of adipokines including chemerin that seems to be related to patho-mechanism of NAFLD. Chemerin seems to besuitable non-invasive biomarker in predicting and quantifying liver steatosis.
Therefore noninvasive methods including imaging techniques and blood test based markers have been developed to qualify and quantify liver steatosis.
The aim of this work was to validate the diagnostic value of serum chemerin, NAFLD Fibrosis Score and sonograghic parameters in detection and quantification of liver steatosis and determining further need for liver biopsy to establish NAFLD diagnosis.