الفهرس | Only 14 pages are availabe for public view |
Abstract Prevalence of end stage renal disease (ESRD) in Egypt raised to 483 patients per million according to 9th Annual Report of The Egyptian Renal Registry provided by Egyptian Society of Nephrology and Transplantation (ESNT). The prevalence of ESRD rising over the last decades, driven by population aging, and increasing prevalence of diabetes mellitus and hypertension Mostafa, et al., 2019. Both cardiovascular and infectious causes of death are linked to inflammation and it has become increasingly appreciated that ESRD is characterized by a state of chronic -inflammation. Hemodialysis (HD) provides increased opportunities for endotoxin influx, recurrent infections, and immune activation leading to chronic systemic inflammation. In healthy individuals, studies have consistently shown an inverse association between markers of systemic inflammation and frequency of physical exercise Kristen et al., 2010. Physical exercise plays a key-role as nonpharmacological treatment of CKD. Exercise in dialysis patients has been shown to decrease oxidative stress, improve endothelial function and reduce cardiovascular risk factors. Furthermore, it may also reduce the inflammatory process in these patients. The aim of this study was to assess the effect of intradialytic aerobic Summary (84) exercise on inflammatory markers in prevalent hemodialysis patients. This study was conducted on Forty adult patients randomly selected from hemodialysis unit of Ain Shams University Hospital. They were divided into two groups the exercise group (A) treated by intradialytic aerobic exercise using a cycle ergometer and the non-exercise group (B) and all subjects in both groups were evaluated 2 times (pre and post treatment) through CRP, IL6 and short battery tests for assessing physical activity before and after treatment. The finding of this study showed significant decrease of CRP and IL6, and improvement in lipid profile and physical activity in the exercise group compared with the non-exercise group. In conclusion, the implementation of exercise training programs during hemodialysis can improve physical functioning, inflammatory markers and lipid profile. New strategies are necessary to bring exercise programs to elderly patients with higher comorbid conditions |