الفهرس 
Inflammation and end stageOnly 14 pages are availabe for public view
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Abstract
Prevalence of end stage renal disease (ESRD) in Egypt
raised to 483 patients per million according to 9th Annual
Report of The Egyptian Renal Registry provided by
Egyptian Society of Nephrology and Transplantation
(ESNT). The prevalence of ESRD rising over the last
decades, driven by population aging, and increasing
prevalence of diabetes mellitus and hypertension Mostafa,
et al., 2019.
Both cardiovascular and infectious causes of death are
linked to inflammation and it has become increasingly
appreciated that ESRD is characterized by a state of chronic
-inflammation. Hemodialysis (HD) provides increased
opportunities for endotoxin influx, recurrent infections, and
immune activation leading to chronic systemic
inflammation. In healthy individuals, studies have
consistently shown an inverse association between markers
of systemic inflammation and frequency of physical
exercise Kristen et al., 2010.
Physical exercise plays a key-role as nonpharmacological
treatment of CKD. Exercise in dialysis
patients has been shown to decrease oxidative stress,
improve endothelial function and reduce cardiovascular
risk factors. Furthermore, it may also reduce the
inflammatory process in these patients. The aim of this
study was to assess the effect of intradialytic aerobic
Summary
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exercise on inflammatory markers in prevalent
hemodialysis patients.
This study was conducted on Forty adult patients
randomly selected from hemodialysis unit of Ain Shams
University Hospital. They were divided into two groups the
exercise group (A) treated by intradialytic aerobic exercise
using a cycle ergometer and the non-exercise group (B) and
all subjects in both groups were evaluated 2 times (pre and
post treatment) through CRP, IL6 and short battery tests for
assessing physical activity before and after treatment.
The finding of this study showed significant decrease
of CRP and IL6, and improvement in lipid profile and
physical activity in the exercise group compared with the
non-exercise group. In conclusion, the implementation of
exercise training programs during hemodialysis can
improve physical functioning, inflammatory markers and
lipid profile. New strategies are necessary to bring exercise
programs to elderly patients with higher comorbid
conditions