الفهرس 
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Abstract
Odontogenic lesions, cysts or tumors are those lesions arising in the jaws or oral soft tissues from the remnants of odontogenic tissues. They vary significantly in size and severity. Some of them, like AB and OKC, have the ability to be aggressive and invade the surrounding bone and tissues, while the majority of them are totally benign in behavior, like DC.
Odontogenesis depends on complex interactions between odontogenic epithelium and odontogenic ectomesenchyme resulting in the development of the tooth and its supporting structures. So, it is now believed that formation of odontogenic lesions is also dependent on the connective tissue components (tumor-associated fibroblasts, endothelial and inflammatory cells) besides the proliferating epithelial cells.
Angiogenesis, which is known as the formation of new blood vessels from the old ones, is believed to have a great role in supporting the growth of neoplastic epithelium, by supplying it with oxygen and nutrients. It also plays a role in invasion and metastasis. CD105 is considered the most accurate angiogenic marker for newly formed blood vessels.
MFs are fibroblasts with special characteristics resembling those of smooth muscles. They differ from the normal fibroblast by the presence of a contractile apparatus and found in the connective tissue stroma of various invasive and metastatic malignant tumors. Between all markers of MFs, α-SMA is considered the best.
This study was carried out to investigate, immunohistochemically, CD105 and α-SMA expression in DC, OKC and AB and to detect if a possible correlation existed between the expression of CD105 and α-SMA in the three lesions.
The material of this study consisted of thirty formalin-fixed, paraffin-embedded specimens of DC, OKC and AB (ten of each). Immunohistochemical staining using the anti-CD105 antibody and the anti-α-SMA antibody was performed by the biotin-streptavidin immunoperoxidase technique. The immunostained slides were examined by light microscopy and photographed. The photomicrographs were then analyzed using image analysis software. For all positive cases, the area fraction of immunopositivity for four different microscopic fields was measured. The mean area fraction for each case was then calculated to be used for statistical analysis.
Immunohistochemical results of the present study revealed 100% CD105 and α-SMA immunopositivity in all cases of DC, OKC and AB.
CD105 expression in AB was higher than OKC with a statistically significant difference, and higher in OKC than in DC with also a statistically significant difference.
α-SMA expression in AB was higher than OKC with a non-statistically significant difference, and higher in OKC than in DC with a statistically significant difference.
According to the obtained data, it could be concluded that MVD and MFs have a direct correlation in all cases and play an important role in the aggressiveness of the studied lesions.