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Abstract Cancer has become one of the most common depletating systemic diseases, and it’s responsible for a large number of worldwide deaths annually. Cancer diagnosis has nearly always associated with malnutrition with different degrees, starting from appetite loss leading to entangled oral supply ending with malignant cachexia and sarcopenia and finally may be death from deteriorated general and nutritional condition and unbalanced essential body needs. Noticeably , patients with cancer don’t all have the same degrees of malnutrition, varied widely according to the site of cancer, its type, the general condition of the patient, symptoms associated and treatment modality the patient received. Patients with Head and Neck tumors and those with GI malignancies are affected most. Mainly due to the disease burden, dominant certain histopathology and symptoms experienced by the patient that can interfere with oral intake as mucositis, gross lesions, dysphagia, altered taste, or obsecure the absorption of the essential elements. Not only does the cancer itself affect the nutritional status of the patient, but also anti cancer treatments have a vast role in modulating the patient’s nutritional health. Chemotherapy as a systemic treatment has a generalized effect on the patient health with multiple side effects, on the other hand, radiotherapy as a local treatment have much less side effects , however side effects are aggrevated in cases of head and neck and GI tumors due to direct mucosal injury. A combined regimen of both chemo and radiotherapy has the side effects of both. |