الفهرس 
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Abstract
Objective: The aim of this study was to make a comparison between the effects of Letrrozole and a combination of Clomiphene Citrate and Tamoxifen in ovulation induction in Clomiphene Citrate – resistant women with polycystic ovary syndrome.
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting about 6-15% of women of reproductive age causing several medical problems mainly infertility. Ovulation induction can be achieved by administration of an oral drug or a combination of drugs as Clomiphene Citrate, Tamoxifen and Letrozole which are considered the first line treatment for anovulatory PCOS
Patients and Methods: This prospective comparative study has been performed at the outpatient clinic of Obstetrics and Gynecology of both Menoufia University Hospital and Quesna Central Hospital during the period from December 2018 to March 2020. One hundred patients with PCOS (resistant to CC) were selected according to ”Rotterdam criteria” including biochemical hyperandrogenism.
Results: There were no statistically significant differences between group (A) 40 cases and group (B) 39 cases as regarding age, BMI and duration of infertility. The results of both groups as regard ovulation rate (OR) were comparable with no significant difference between the two groups.
Conclusion: The results of the present study are comparable to previous reported studies revealing that CC, tamoxifen and letrozole are effective in treatment of infertility in PCOS patients. Addition of tamoxifen to CC enhances its effect and give better results.
Key words: Clomiphene Citrate, Letrozole, Ovulation Induction, PCOS, Tamoxifen.