الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: In myocardial infarction (MI) patients, myocardial reperfusion and subsequently, early infarct related artery (IRA) patency are very critical in this emergency situation. Recently, there is growing research on the ability of platelet to lymphocyte ratio (PLR) to be a predictor of outcomes as well as a marker for inflammation and coagulopathy detection. This study aimed to assess The relationship between PLR and the patency of IRA in patients with STEMI before primary percutaneous intervention(pre PPCI).
ST-segment elevation myocardial infarction (STEMI) occurs as a result of atherosclerotic plaque rupture (or erosion), superimposed thrombus formation, and coronary occlusion after all. Inflammation and thrombosis display an important interaction with each other during this pathophysiological process.(1,2) Moreover, it has been shown that patency of infarct-related artery (IRA) before primary percutaneous coronary intervention (pre-pPCI) determines the postprocedural success, in-hospital mortality, and better preservation of ventricular performance.(3)
Although there have been considerable improvements in the diagnostic and treatment strategies of CVD, the number of patients with CVD and the costs of the disease are increasing exponentially. (4-6) It is obvious that there is a need for more practical and economical diagnostic, therapeutic, and prognostic strategies. The role of inflammatory markers in CVD has been studied extensively and a consistent association between increased inflammatory markers and various CV events including mortality has been established.(7-12) Platelets release thromboxanes, pro-inflammatory chemokines, growth factors such as transforming growth factor b1, vascular endothelial growth factor, insulin growth factor, platelet-derived growth factor, and cytokines, which participate in vascular inflammation and thrombosis(13,14) Platelet activation plays an important role in all steps of coronary artery disease (CAD).(15) Activated platelets take part in thrombus formation in response to atherosclerotic plaque rupture or endothelial cell erosion, promoting the development of atherothrombotic disease or adverse CV events.(16) On the other hand, the lymphocyte count is an indicator of physiologic stress,(17)and it is inversely associated with inflammation; a lower lymphocyte count represents increased CV risk and mortality.