الفهرس | Only 14 pages are availabe for public view |
Abstract Edible oils, preferably of plant origin are rich sources of fatty acids and other lipophilic antioxidants that assist in the prevention and/ or treatment of some diseases. This study aimed to investigate the possible protective effects of some plant oils on cement induced liver toxicity and kidney dysfunction in rats. Forty Sprague Dawley rats (20 male + 20 female) were divided into five groups (8 rats/group, four males and four females). Group1: negative control, was fed on a basal diet; group II: positive control, was fed on a basal diet contains cement (1.5 g/Kg); groups III, IV, V were fed on basal diet contain cement (1.5g/Kg) and 10 % of one the tested oils (coconut oil, or flaxseed oil or olive oil, respectively, instead of corn oil) the experiment continued for four weeks. RESULTS: Oral cement exposure resulted in a significant elevation in serum activity of alanine transaminase (ALT), Aspartate transaminase (AST), and lactate dehydrogenase (LDH) in addition to significant high levels of serum urea and creatinine. This was accompanied by a significant rise in the hepatic level of malondialdehyde (MDA). Plant oils reinstated most of the altered measured parameters. Histological examination of the liver, kidney, lungs, and brain revealed that cement exposure resulted in fibrosis in the portal triad, and focal hepatic hemorrhage, hydropic degeneration of epithelial lining renal tubules, interstitial pneumonia, and necrosis of neurons and neuronophagia. While the histological examinations in the tested oils groups revealed improvement in these organs. It can be concluded that supplementation of the diet with coconut oil, flaxseed oil, or olive oil was effective in modulating some aspects of cement induced toxicity. This efficacy may be related to the fatty acids and/ or polyphenols found in these oils. The study indicates that coconut oil, flaxseed oil, and olive oil can be used as nutraceutical agents against cement induced toxicity. |