الفهرس 
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Abstract
Endophthalmitis is a sight-threatening inflammation of the eye. For patients and surgeons alike, one of the most feared complications of cataract surgery is acute postoperative endophthalmitis. With over 10 million cataract surgeries performed worldwide every year, effective POE prophylaxis is necessary. Povidone-iodine solution has historically been the standard for POE prophylaxis, but other modalities include intracameral (IC), topical, subconjunctival and oral antibiotics. Of the identified risk factors for POE, many authors state that both the route of administration and the type of antibiotic are important factors for risk mitigation, which has led to an increased number of IC antibiotic studies. Currently, although IC administration is widely accepted, there is no consensus on the best prophylactic therapy or route of administration for POE prevention. This study was conducted to determine the safety of prophylactic intracameral injection of moxifloxacin after uncomplicated phacoemulsification surgery. This case control study included 60 eyes of patients who had uncomplicated phacoemulsification cataract surgery selected from Mansoura ophthalmic center, Mansoura University, Egypt, in the period from August 2017 to August 2018. After obtaining a written informed consent, in the preoperative period, the cases were subjected to full history taking and full ophthalmological examination including assessment of central corneal thickness and endothelial cell count. After the surgery the cases were classified into two groups. The first group (30 eyes) received ordinary postoperative systemic and topical ocular treatment (Control group) and the second group (30 eyes) received ordinary postoperative systemic and topical ocular treatment in addition to injection with intracameral moxifloxacin at the end of surgery. The cases were followed up at the following up at; first day,1 week, 1 month & 3 months after surgery. The results of this study showed that : * There was no statistically significant difference between the two groups in the basic data including age and sex. * There was no statistically significant difference in the UCVA , BCVA, the central corneal thickness and endothelial cell count in the cases within the two groups in the preoperative period. * There was no statistically significant difference in the number of cells in anterior chamber in the first day after the operation in the cases within the two groups. * There was no statistically significant difference in the BCVA, central corneal thickness and endothelial cell count in the cases within the two groups after 1 week of surgery. * There was statistically significant difference in the BCVA, but there was no statistically significant difference in the central corneal thickness and endothelial cell count in the cases within the two groups 1 and 3 months of surgery. * There was a statistically significant decrease in the central corneal thickness, endothelial cell count and number of cells in anterior chamber in the cases within the two groups along the follow up period after the surgery as compared with the preoperative value.