الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Ultrasound is commonly used in association with mammography in the assessment of clinically or mammographically suspicious breast lesions. Ultrasonography provides information on acoustic properties that are useful in characterizing breast masses, which helps in the proper diagnosis and management of breast lesions.
Treatment and prognosis for breast cancer varies according to histologic grade and biological markers such as expression of ER and PR, amplification of HER2-neu oncogene, and the proliferation of the Ki-67 antigen. Accurate and early evaluation of breast cancer, based on these prognostic indicators, is helpful in treatment planning; therefore, more attention is needed toward imaging to determine whether such prognostic factors can be predicted by imaging.
The imaging characteristics of breast cancer in general have been studied for a long time, which has been useful in differentiating benign from malignant tumors as outlined in the BI-RADS. Not enough research has focused on the correlation between the current BI-RADS imaging categorization of sonographic features and the hormone receptor status of breast cancer, their results often agreed but also showed some discrepancies. Other sonographic features like mass shape, orientation, vascularity and architectural distortion needed more focus.
Our study included a total of 97 female patients diagnosed with breast cancer following ultrasound assessment, ultrasound-guided core biopsy, and histopathological and immunohistochemical analysis in the time-period from May 2018 to May 2019 in the department of radiology in Ismailia Cancer Teaching Hospital.
Our study demonstrated a significant association between triple negative breast cancer and regular shape, non-spiculated margins, and absent posterior shadowing. Posterior shadowing and spiculated margins were associated with ER/PR receptor positivity. Her2/neu overexpression was strongly associated with microcalcifications. Using these characteristics shows a great value in prognosis and will help in accurate and early treatment planning based on non-invasive and readily available ultrasound assessment.