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Abstract Rosacea is a chronic skin condition that primarily affects the central face, and is often characterized by flare-ups and remissions. It is often mistaken for acne, eczema, or a skin allergy. It typically begins after age of 30 as flushing or redness on the cheeks, nose, chin or forehead. Based on morphological characteristics, rosace is generally classified to: erythematotelangiectatic, papulopustular, phymatous, and ocular. Medications and topical irritants have also been known to trigger rosacea flares. Some acne and wrinkle treatments reported to cause rosacea include microdermabrasion and chemical peels, as well as high dosages of isotretinoin, benzoyl peroxide, and tretinoin Vitamin D and calcium are often used in the same sentence because they work closely together, vitamin D’s primary role is to control the levels of calcium found in the blood stream by constantly allowing calcium and phosphate absorption from the intestine or taking calcium from bones. the unique relationship that entangles vitamin D to dermatology, that is our skin is one source for this important vitamin and on the other hand all available data point to its important impact on the health of our skin and the involvement of its deficiency in the pathway of many dermatological diseases. The precise pathogenesis of rosacea remains unknown, but it was recently reported that cathelicidin, an antimicrobial peptide (AMP) related to innate immunity, was increased in rosacea Recent studies have shown that microorganisms such as Demodex, Staphylococcus epidermidis, and Bacillus oleronius may |