Author: Ghareeb,Neveen Nabil/ Title: THE SENSITIVITY AND SPECIFICITY OF USING SALIVARY EXTRACELLULAR VESICLES AS NON –INVASIVE SOURCE OF MIRNAS (MIRNA-412, MIRNA-512) IN THE DETECTION OF MALIGNANT TRANSFORMATION OF POTENTIALLY MALIGNANT ORAL LESIONS

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العنوان

THE SENSITIVITY AND SPECIFICITY OF USING SALIVARY EXTRACELLULAR VESICLES AS NON –INVASIVE SOURCE OF MIRNAS (MIRNA-412, MIRNA-512) IN THE DETECTION OF MALIGNANT TRANSFORMATION OF POTENTIALLY MALIGNANT ORAL LESIONS

المؤلف

Ghareeb,Neveen Nabil

هيئة الاعداد

باحث / نيفين نيبل غريب

مشرف / فتحيه محمد زهران

مشرف / ايمن عبد الوهاب

مشرف / الفت شكر

الموضوع

SALIVARY ORAL LESIONS. POTENTIALLY

تاريخ النشر

2020

عدد الصفحات

148:

اللغة

الإنجليزية

الدرجة

الدكتوراه

التخصص

Periodontics

تاريخ الإجازة

1/1/2020

مكان الإجازة

جامعة القاهرة - الفم والأسنان - Oral Medicine

الفهرس

Only 14 pages are availabe for public view

from

169

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169

Abstract

The study was designed to evaluate the sensitivity and specificity of using the salivary extracellular vesicles as a non -invasive source of (miRNA-412, miRNA-512) to detect the malignant transformation of the potentially oral premalignant lesions using qRT-PCR analysis.
Research hypothesis:
In patients with potentially malignant lesions, does Quantitative real-time polymerase chain reaction (qRT-PCR) analysis for salivary extracellular vehicles (EVs) miRNAs (miRNA-412, miRNA-512) help to discriminate between potentially malignant lesions and control normal cases, in equality to tissue biopsy?