الفهرس 
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Abstract
The thesis aims to the fabrication of zinc ferrite nanoparticles using different methods. The obtained zinc ferrite used for the formation of the composite with the modified chitosan. The synthesized composites can be used as drug delivery systems for doxorubicin. The thesis consists of three main chapters as the following.
Chapter (I): Introduction
The introduction consists of the knowledge and the basic of nonmaterials, the preparation methods and their applications in various fields. This chapter also has a literature survey on the past work done on zinc ferrite nanostructure and it’s composite with chitosan and their various applications in different fields.
Chapter (II): Experimental
This chapter includes the experimental part of this thesis. It has a complete description of chemicals, reagents and methods for the preparation and the applications. The preparation of zinc ferrite by using auto combustion method and co-precipitation method. Also, the modified chitosan using simple method with glutaraldehyde and poly vinyl alcohol. The obtained zinc ferrite and the modified chitosan used for the preparation of CSG/zinc ferrite composite. The prepared composite was used as drug delivery for doxorubicin. This chapter describes the composition and structure of the selected drug. The factors affecting the loading and release the drug studied. This chapter has the description of the characterization tools for the synthesized materials (XRD, FTIR, FE-SEM and HR-TEM techniques).
Chapter III: Results and discussion
It can be divided into two parts as the following:
Part 1: characterization of the synthesized material
It shows the characterization of the prepared zinc ferrite and their composite with the modified chitosan. Zinc ferrite nanoparticles were fabricated by auto-combustion and co-precipitation methods. The zinc ferrite products were characterized by utilizing as XRD, FTIR, FE-SEM and HR-TEM techniques. The crystallite sizes of samples were determined using XRD and TEM techniques and both techniques determine particle and crystalline size in the nano rang. FT-IR spectra of the prepared samples showed bands at ” " ~ " ”564 and 436 cm-1 that can be assigned to the formation of ZnFe2O4 spinel. FTIR displays the masking the bands related to the spinel structure after the formation of the composite with chitosan. TEM and SEM images described the appearance of spherical and hexagonal shapes depending on the nature of sample and the method of preparation.
Part two: application part
a) Loading of doxorubicin on zinc iron nanoparticles and chitosan individually as well as their composite. This results showed that the drug loading capacity for them ranged between (9%-94%), which indicate a relatively high diversity in drug loading efficiency.
b) Medicine release of doxorubicin loaded on ZnFe2O4, modified chitosan and modified chitosan/zinc ferrite nanocomposites. This part shows that doxorubicin could be continuously released the best result of drug release always at low pH value with all different drug carriers.
c) Cell viability and Estimation of cytotoxicity against HCT-119 cell and MCF-7 cells line. Results of that study showed that the worst result against cancer cells with CSG/ZnFe2O4 nanoparticles prepared by combustion and co-precipitation without Doxorubicin, and CSG/ZnFe2O4 composite prepared by combustion and co-precipitation that showed the best results against cancer cells.