الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
 |  | from | 107 |  |  |
| | | from | 107 | | |
Abstract
Thalassemia is a public health problem worldwide including but not exclusively Egypt. Incidence is highest in the Mediterranean, the Middle East, North America and South East Asia and incidence is increasing worldwide as a result of migration. In Egypt, β-Thalassemia is the most frequent hemoglobinopathy, therefore incidence of iron overload complications due to regular blood transfusion is our main concern in this study. Early detection of iron overload using fast and cheap techniques was the main focus of our study.
Aim of the study
The aim of this work was to detect cardiac and liver affection due to iron overload by cardiac and liver MRI T2* in relation to echocardiography and liver Fibroscan in pediatric patient with β-thalassemia major.
Subject and methods
To achieve these objectives, a case-control study was carried on 40 patients aged between 9 years to 18 years old, 23 (57.5%) males and 17 (42.5%) females. The studied cases were taken from the Pediatric Department of Hematology and oncology of Menoufia University Hospital.
Data collection was carried out using a field presented interviewing.
Summary
- 74 -
Questionnaire covering the following elements:
- Child age, sex, residence (urban or rural).
- All children were subjected to complete blood picture.
- Serum ferritin level was done for all patients.
- Echocardiography for all studied cases.
- Fibroscan for all studied cases.
- MRI T2* on the heart and liver for all studied cases.
Results
The age range of the studied children was between 9 years – 18 years with a mean of 13 years. 23 were males (57.5%) and 17 were females (42.5%). 22 were consanguineous (55%) while 18 were non-consanguineous (45%). The mean weight was 40.60 kg while the mean height was 145 cm.
Our study showed that gender has no relationship with thalassemia, there was slight male predominance (23) and female (17) but differences was of no significance (p > 0.82). Our study shows positive consanguinity rate (55%) in thalassemia patients than non-consanguineous (45%) with a significance value to this study (p 0.02) and the BMI for patients with thalassemia was significantly decreased (p < 0.04) than those of the control group, children were underweight and malnourished.
Our study shows predominance of rural cases (77.5%) than urban cases (22.5).
Our study shows microcytosis prevalence in thalassemia patients compared to the control with MCV mean of 73 fl (p <0.001) and MCH mean of 27 pg, being highly significant.
Summary
- 75 -
Our study shows the serum ferritin levels among thalassemic patients was higher than the controls reaching a mean of 3613 ng/ml proving its high significance. Our study showed that there is a strong correlation between Liver Fibroscan and MRI T2* (p = 0.03). Our study showed significant positive correlation between EF% (p 0.04), LVEDD (p 0.02), LVESV (p 0.01) and cardiac T2* among studied thalassemia patients.