الفهرس 
الغلافOnly 14 pages are availabe for public view
 |  | from | 163 |  |  |
| | | from | 163 | | |
Abstract
Many years agoOver the second half of the past century, natural products have been used as major source of the discovery anti-cancer medicine. However, there is a consistent demand for new anti-cancer drugs with high efficacy and minimal side-effects. This study aims to investigate the anti-cancer activity for seven plant extracts cultivated in Egypt plant extracts (Grevillea robusta; Euphorbia millii; Euphorbia royleana; Aloe grandidentata; Bauhinia corniculate; Cassia fistula and Pinus palustris). First, all theseplant extracts were phytochemically screened for the presence of bioactive metabolites as saponins, tannins, cardiac glycosides, alkaloids, flavonoids, anthraquinones and sterols to uncover their chemical diversity using qualitative tests. Antiproliferative screening assay of each plant extract was performed on a panel of three cancer cell-lines (HepG-2, HCT-116 and MCF-7) with different concentrations using MTT assay in comparison to WI-38 human normal fibroblast cell line. The results showed that E. royleana, A. grandidentata and P. palustris extracts significantly reduced HepG-2 cellular growth with IC50 of 0.42, 0.53 and 0.2 µg/mL, respectively and P. palustris reduced HCT-116 cellular growth with IC50 of 0.11 µg/mL. Moreover, A. grandidentata, C. fistula and P. palustris reduced cellular growth of MCF-7 with IC50 of 0.37, 0.67 and 0.11 µg/mL, respectively. Three compounds were successfully isolated namely, Rubastaside D from G. Robusta; flavonoid of a kaempferol nucleus from E. millii and Abietic abietic acid from P. palustris